Pharmaceutical product.



sarns PATENT LUDWIG TAUB, OF ELBERFELD. GERMANY, ASSIGNOR TOFARBENFABRIKEN VORM. FRIEDR. BAYER & 00., OF ELBERFELD, GERMANY, ACORPORATION OF GERMANY.

PHARMACEUTICAL PRODUCT.

No Drawing.

Be it known that I, LUDWIG TAUB, doctor of philosophy, chemist, citizenof the German Empire, residing at Elbert'eld, Ger many, have inventednew and useful Improvements in New Pharmaceutical Prodnets, of which thefollowing is a. specification.

It has been observed that the salts of the hitherto unknown mercuriccompounds of substituted phenols containing two or more substitutes,especially alkyl-, halogen-, alkoxyor 'alkylhalogen-phenols substitutedin the nucleus have a disinfectant power, superior in many cases to thatof sublimate, especially in the presence of soap or of serum. The abovementioned compounds are therefore therapeuticallyvaluable products.

The new bodies containing in the shape of the anhydrids in theirmolecule the characteristic group o R/ l in which R stands forpoly-substituted benzene nucleus, are obtained by treating thecorresponding phenols with mercuric oxid or mercuric salts at hightemperatures or by heating e. g. the mercuric salts of the phenols inpresence or absence of fusion agents or solvents. The new products areinsoluble or diflicultly soluble in water whitish crystalline compoundswhich are soluble in dilute alkalis forming salts and insoluble in etherand benzene. On being boiled with hydrochloric acid they are split up,HgCl being produced.

In order to illustrate the new process more fully the following exampleis given, the parts being by weight :12 parts of lA-di- 'methyl-phenol(para-xylenol) dissolved in 100 parts of methyl-alcohol are heated with30 parts of mercuric-acetate in 100 parts of water until a test portionof the melt forms a clear solution with caustic soda lye. After coolingthe new compound crystallizes from the llquid. By passing carbonic acidSpecification of Letters Patent.

Application filed March 2. 1912.

Patented Sept. 23, 1913.

Serial No. 681,302.

through the solution in alkali the anhydrid of theoxy-mercuric-dimethylphenol:

/'\ o cit is precipitated as a fine white crystalline powder. It isalmost insoluble in water and the usual organic solvents, but it is Veryeasily soluble in alkalis forming the corresponding salts. By heating itwith by drochloric acid the compound is split up into dimethyl 'ihenoland mercuric ehlorid. On being heated it is decomposed without melting.Also other of the above mentioned phenols can be used,-e. g. creosol(3-met-hylether of homopyrt:catechin), pyrogallol-diethylether,bromxylenol, etc.

1. As new products, mercuric compounds of unsulfonated phenolssubstituted in the nucleus by at least two substituents containing inthe shape of the anhydrids in their molecule the characteristic group:

Hg in which R stands for an unsulfonated polysu-bstituted benzenenucleus, which are whitish crystalline compounds soluble in dilutealkalis forming salts, insoluble in water,

ether and benzene, splitting off Hg 1 on.

being boiled with h 'drochloricacid; and be? ing valuable disin ectants,substantially as are whitish crystalline compounds soluble in dilutealkalis forming salts," insoluble in water, ether and benzene, splittingofi' HgCl, on being boiled with hydrochloric acid; and being valuabledisinfectants, substantially as described.

3. As new products, mercuric compounds of unsulfonated phenolssubstituted in the nucleus by at least two substituents containing inthe shape of the anhydrid-in their molecule the characteristic group:

nucleus by at least two substituents containing in the shape of theanhydrids in their molecule the characteristic group:

in which R stands for a polymethyl sub stituted benzene nucleus, whichare whitish crystalline compounds soluble in dilute alkalis formingsalts, insoluble in water, ether and benzene, splitting off HgCl onbeing boiled with hydrochloric acid; and being valuable disinfectants,substantially as described.

5. As new products, mercuric compounds of unsulfonated phenolssubstituted in the nucleus by at least two substituents containing inthe shape of the anhydrids in their molecule the characteristic group:

in which R stands for a dimethyl substituted benzene nucleus, which arewhitish crystalline compounds soluble in dilute alkalis forming salts,insoluble in water, ether and benzene, splitting off HgCl on beingboiled with hydrochlonc acid; and being-valuable disinfectants,substantially as described.

' 6. As new products, mercuric compounds of phenols substituted in thenucleus by at least two substituents containing in the shape of theanhydrid in their molecule the characteristic group \Hg 7 in which Rstands for a polyalkyl substituted benzene nucleus, which are whitishcrystalline compounds soluble in dilute alkalis forming salts, insolublein water, ether and benzene, splitting ofi HgOl on being boiled withhydrochloric acid; and being valuable disinfectants, substantially asdescribed. n

7. As new products, mercuric compounds of phenols substituted in thenucleus by at least two substituents containing vin the shape of theanhydrid in their molecule the characteristic group:

in which It stands for polymethyl substituted benzene nucleus, which arewhitish crystalline compounds soluble in dilute alkalis forming salts,insoluble in water, ether and benzene, splitting ofi' HgCl on beingboiled with hydrochloric acid; and being valuable disinfectants,substantially as de-. scribed.

8. As new roducts, mercuric compounds of phenols su stituted in. thenucleus by at least .two substituents containin in the shape of theanhydrid in their mo sonic the characteristic group:

in which R stands for a 'dimethyl substi tuted benzene nucleus, whichare whitish crystalline compounds soluble in dilute alkalis formingsalts, insoluble in water, ether and benzene, splitting off ll-IgCl onbeing I boiled with hydrochloric acid; and being valuable disinfectants,substantially as described. 1

In testimony whereof I have hereunto set my hand in the presence of twosubscribing witnesses.

LUDWIG TAUB. [11. s.] Witnesses:

HELEN NUFER,

A. Nurse.

